Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats

PURPOSE: This study aims to evaluate the beneficial effects of anti-epileptic mechanisms of baicalin (BA) on cognitive dysfunction and neurodegeneration in pentylenetetrazol (PTZ)-induced epileptic rats. METHODS: First, PTZ-induced epileptic rats were administered intraperitoneally a sub-convulsive...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Yang, Jiali, Jia, Zhixia, Xiao, Zhigang, Zhao, Jing, Lu, Ye, Chu, Li, Shao, Hui, Pei, Lin, Zhang, Shaodan, Chen, Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312624/
https://ncbi.nlm.nih.gov/pubmed/34321866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S314076
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