In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)- and TCR-redirected T cells, several clinical studie...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Bonte, Sarah, de Munter, Stijn, Billiet, Lore, Goetgeluk, Glenn, Ingels, Joline, Jansen, Hanne, Pille, Melissa, de Cock, Laurenz, Weening, Karin, Taghon, Tom, Leclercq, Georges, Vandekerckhove, Bart, Kerre, Tessa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2021
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312599/
https://ncbi.nlm.nih.gov/pubmed/34367734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1954800
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