Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect

Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers. We studied and compared the in vitro, in vivo, and in silico effects of some crambescine A and C analogs. HepG2 gene expression was analyz...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Rubiolo, Juan A., Lence, Emilio, González-Bello, Concepción, Roel, María, Gil-Longo, José, Campos-Toimil, Manuel, Ternon, Eva, Thomas, Olivier P., González-Cantalapiedra, Antonio, López-Alonso, Henar, Vieytes, Mercedes R., Botana, Luis M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312399/
https://ncbi.nlm.nih.gov/pubmed/34322022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.694639
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