Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect

Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers. We studied and compared the in vitro, in vivo, and in silico effects of some crambescine A and C analogs. HepG2 gene expression was analyz...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Rubiolo, Juan A., Lence, Emilio, González-Bello, Concepción, Roel, María, Gil-Longo, José, Campos-Toimil, Manuel, Ternon, Eva, Thomas, Olivier P., González-Cantalapiedra, Antonio, López-Alonso, Henar, Vieytes, Mercedes R., Botana, Luis M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312399/
https://ncbi.nlm.nih.gov/pubmed/34322022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.694639
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