Treatment of testicular relapse of B-cell acute lymphoblastic leukemia with CD19-specific chimeric antigen receptor T cells

BACKGROUND: Irradiation has been a standard treatment for testicular relapse but is associated with severe hypogonadism. Because CD19-specific CAR-T cells can eradicate leukemic blasts in cerebrospinal fluid, a pharmacologic sanctuary site, we tested the efficacy of this therapy in seven boys with i...

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Publicado en:Clin Lymphoma Myeloma Leuk
Main Authors: Chen, Xiaojuan, Wang, Ying, Ruan, Min, Li, Jun, Zhong, Mengjun, Li, Zhanqi, Liu, Fang, Wang, Shuchun, Chen, Yumei, Liu, Lipeng, Yang, Jun J, Zhu, Xiaofan, Wang, Jianxiang, Pui, Ching-Hon
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312220/
https://ncbi.nlm.nih.gov/pubmed/32205078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clml.2019.10.016
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