Lataa...
Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome
[Image: see text] Intracellular chloride concentration [Cl(–)](i) is defective in several neurological disorders. In neurons, [Cl(–)](i) is mainly regulated by the action of the Na(+)–K(+)–Cl(–) importer NKCC1 and the K(+)–Cl(–) exporter KCC2. Recently, we have reported the discovery of ARN23746 as...
Tallennettuna:
| Julkaisussa: | J Med Chem |
|---|---|
| Päätekijät: | , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Chemical Society
2021
|
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8311653/ https://ncbi.nlm.nih.gov/pubmed/34137257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00603 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|