Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome

[Image: see text] Intracellular chloride concentration [Cl(–)](i) is defective in several neurological disorders. In neurons, [Cl(–)](i) is mainly regulated by the action of the Na(+)–K(+)–Cl(–) importer NKCC1 and the K(+)–Cl(–) exporter KCC2. Recently, we have reported the discovery of ARN23746 as...

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Publicado en:J Med Chem
Main Authors: Borgogno, Marco, Savardi, Annalisa, Manigrasso, Jacopo, Turci, Alessandra, Portioli, Corinne, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Armirotti, Andrea, Contestabile, Andrea, Cancedda, Laura, De Vivo, Marco
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2021
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8311653/
https://ncbi.nlm.nih.gov/pubmed/34137257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00603
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