Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome

[Image: see text] Intracellular chloride concentration [Cl(–)](i) is defective in several neurological disorders. In neurons, [Cl(–)](i) is mainly regulated by the action of the Na(+)–K(+)–Cl(–) importer NKCC1 and the K(+)–Cl(–) exporter KCC2. Recently, we have reported the discovery of ARN23746 as...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Borgogno, Marco, Savardi, Annalisa, Manigrasso, Jacopo, Turci, Alessandra, Portioli, Corinne, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Armirotti, Andrea, Contestabile, Andrea, Cancedda, Laura, De Vivo, Marco
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8311653/
https://ncbi.nlm.nih.gov/pubmed/34137257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00603
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker