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Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome
[Image: see text] Intracellular chloride concentration [Cl(–)](i) is defective in several neurological disorders. In neurons, [Cl(–)](i) is mainly regulated by the action of the Na(+)–K(+)–Cl(–) importer NKCC1 and the K(+)–Cl(–) exporter KCC2. Recently, we have reported the discovery of ARN23746 as...
Guardat en:
| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2021
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8311653/ https://ncbi.nlm.nih.gov/pubmed/34137257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00603 |
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