Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study

Osteoarthritis (OA) is a prevalent degenerative joint disease. Its development is highly associated with inflammatory response and apoptosis in chondrocytes. Selonsertib (Ser), the inhibitor of Apoptosis Signal-regulated kinase-1 (ASK1), has exhibited multiple therapeutic effects in several diseases...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Yan, Jiyuan, Zhang, Yingchi, Sheng, Gaohong, Ni, Bowei, Xiao, Yifan, Wang, Shanxi, Wang, Tianqi, Ma, Yongzhuang, Wang, Huaixi, Wu, Hua, Tu, Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8311523/
https://ncbi.nlm.nih.gov/pubmed/34322020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.687033
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