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The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy

Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in increased adenosine release, thereby constraining excessive excitation. The exceptionally high neuronal activity of a seizure results in a surge in extracellular adenosine to concentrations many-fold higher t...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Purnell, Benton, Murugan, Madhuvika, Jani, Raja, Boison, Detlev
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8311182/
https://ncbi.nlm.nih.gov/pubmed/34321997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.708304
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