Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

Multiple sclerosis (MS) is an immune-mediated inflammatory disease that leads to demyelination and neuronal loss in the central nervous system. Immune cells of lymphoid and myeloid origin play a significant role in the initiation and amplification of neuronal inflammation in MS. STAT3 signaling play...

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Publicat a:Pharmaceutics
Autors principals: Alhazzani, Khalid, Ahmad, Sheikh F., Al-Harbi, Naif O., Attia, Sabry M., Bakheet, Saleh A., Sarawi, Wedad, Alqarni, Saleh A., Algahtani, Mohammad, Nadeem, Ahmed
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8308768/
https://ncbi.nlm.nih.gov/pubmed/34206429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13070925
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