Simvastatin Reduces Protection and Intestinal T Cell Responses Induced by a Norovirus P Particle Vaccine in Gnotobiotic Pigs

Noroviruses (NoVs) are a leading cause of acute gastroenteritis worldwide. P particles are a potential vaccine candidate against NoV. Simvastatin is a cholesterol-reducing drug that is known to increase NoV infectivity. In this study, we examined simvastatin’s effects on P particle-induced protectiv...

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Bibliographic Details
Published in:Pathogens
Main Authors: Kocher, Jacob, Castellucci, Tammy Bui, Wen, Ke, Li, Guohua, Yang, Xingdong, Lei, Shaohua, Jiang, Xi, Yuan, Lijuan
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8308729/
https://ncbi.nlm.nih.gov/pubmed/34357979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens10070829
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