Indole- and Pyrazole-Glycyrrhetinic Acid Derivatives as PTP1B Inhibitors: Synthesis, In Vitro and In Silico Studies

Regulating insulin and leptin levels using a protein tyrosine phosphatase 1B (PTP1B) inhibitor is an attractive strategy to treat diabetes and obesity. Glycyrrhetinic acid (GA), a triterpenoid, may weakly inhibit this enzyme. Nonetheless, semisynthetic derivatives of GA have not been developed as PT...

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Publicado no:Molecules
Main Authors: De-la-Cruz-Martínez, Ledy, Duran-Becerra, Constanza, González-Andrade, Martin, Páez-Franco, José C., Germán-Acacio, Juan Manuel, Espinosa-Chávez, Julio, Torres-Valencia, J. Martin, Pérez-Villanueva, Jaime, Palacios-Espinosa, Juan Francisco, Soria-Arteche, Olivia, Cortés-Benítez, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8308021/
https://ncbi.nlm.nih.gov/pubmed/34299651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26144375
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