Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of Salmonella enterica Serovar Typhimurium Infection

Arginase 1 (ARG1) is a cytosolic enzyme that cleaves L-arginine, the substrate of inducible nitric oxide synthase (iNOS), and thereby impairs the control of various intracellular pathogens. Herein, we investigated the role of ARG1 during infection with Salmonella enterica serovar Typhimurium (S.tm)....

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Udgivet i:Cells
Main Authors: Brigo, Natascha, Pfeifhofer-Obermair, Christa, Tymoszuk, Piotr, Demetz, Egon, Engl, Sabine, Barros-Pinkelnig, Marina, Dichtl, Stefanie, Fischer, Christine, Valente De Souza, Lara, Petzer, Verena, von Raffay, Laura, Hilbe, Richard, Berger, Sylvia, Seifert, Markus, Schleicher, Ulrike, Bogdan, Christian, Weiss, Günter
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307077/
https://ncbi.nlm.nih.gov/pubmed/34359992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071823
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