Ipragliflozin Ameliorates Diabetic Nephropathy Associated with Perirenal Adipose Expansion in Mice

Sodium glucose cotransporter-2 (SGLT2) inhibitors inhibit the development of diabetic nephropathy (DN). We determined whether changes in perirenal fat (PRAT) by a SGLT2 inhibitor ipragliflozin (Ipra) contribute to the suppression of DN development. High-fat diet (HFD)-fed mice were used as a DN mode...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Okuma, Hideyuki, Mori, Kentaro, Nakamura, Suguru, Sekine, Tetsuo, Ogawa, Yoshihiro, Tsuchiya, Kyoichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8304702/
https://ncbi.nlm.nih.gov/pubmed/34298949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147329
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