Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Efflux transporters, namely ATP-binding cassette (ABC), are one of the primary reasons for cancer chemoresistance and the clinical failure of chemotherapy. Ganciclovir (GCV) is an antiviral agent used in herpes simplex virus thymidine kinase (HSV-TK) gene therapy. In this therapy, HSV-TK gene is del...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Markowicz-Piasecka, Magdalena, Huttunen, Johanna, Montaser, Ahmed, Adla, Santosh Kumar, Auriola, Seppo, Lehtonen, Marko, Huttunen, Kristiina M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8303380/
https://ncbi.nlm.nih.gov/pubmed/34299347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147727
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