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Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone. This bone-to-kidney signal promotes urinary phosphate excretion. I...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Ogura, Yurie, Kaneko, Ryoji, Ujibe, Kota, Wakamatsu, Yuma, Hirata, Hiromi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302672/
https://ncbi.nlm.nih.gov/pubmed/34301962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93909-y
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