Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

Genes are expressed in stochastic transcriptional bursts linked to alternating active and inactive promoter states. A major challenge in transcription is understanding how promoter composition dictates bursting, particularly in multicellular organisms. We investigate two key Drosophila developmental...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Pimmett, Virginia L., Dejean, Matthieu, Fernandez, Carola, Trullo, Antonio, Bertrand, Edouard, Radulescu, Ovidiu, Lagha, Mounia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302612/
https://ncbi.nlm.nih.gov/pubmed/34301936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24461-6
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