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Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

Genes are expressed in stochastic transcriptional bursts linked to alternating active and inactive promoter states. A major challenge in transcription is understanding how promoter composition dictates bursting, particularly in multicellular organisms. We investigate two key Drosophila developmental...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pimmett, Virginia L., Dejean, Matthieu, Fernandez, Carola, Trullo, Antonio, Bertrand, Edouard, Radulescu, Ovidiu, Lagha, Mounia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302612/
https://ncbi.nlm.nih.gov/pubmed/34301936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24461-6
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