An artificial neural network−pharmacokinetic model and its interpretation using Shapley additive explanations

We developed a method to apply artificial neural networks (ANNs) for predicting time‐series pharmacokinetics (PKs), and an interpretable the ANN‐PK model, which can explain the evidence of prediction by applying Shapley additive explanations (SHAP). A previous population PK (PopPK) model of cyclospo...

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Dettagli Bibliografici
Pubblicato in:CPT Pharmacometrics Syst Pharmacol
Autori principali: Ogami, Chika, Tsuji, Yasuhiro, Seki, Hiroto, Kawano, Hideaki, To, Hideto, Matsumoto, Yoshiaki, Hosono, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302242/
https://ncbi.nlm.nih.gov/pubmed/33955705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12643
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