Melorheostotic Bone Lesions Caused by Somatic Mutations in MAP2K1 Have Deteriorated Microarchitecture and Periosteal Reaction

Melorheostosis is a rare non-hereditary condition characterized by dense hyperostotic lesions with radiographic “dripping candle wax” appearance. Somatic activating mutations in MAP2K1 have recently been identified as a cause of melorheostosis. However, little is known about the development, composi...

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Pubblicato in:J Bone Miner Res
Autori principali: Fratzl-Zelman, Nadja, Roschger, Paul, Kang, Heeseog, Jha, Smita, Roschger, Andreas, Blouin, Stéphane, Deng, Zuoming, Cabral, Wayne A, Ivovic, Aleksandra, Katz, James, Siegel, Richard M, Klaushofer, Klaus, Fratzl, Peter, Bhattacharyya, Timothy, Marini, Joan C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302214/
https://ncbi.nlm.nih.gov/pubmed/30667555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3656
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