Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells

Periodontal disease is driven by dysbiosis in the oral microbiome, resulting in over-representation of species that induce the release of pro-inflammatory cytokines, chemokines, and tissue-remodeling matrix metalloproteinases (MMPs) in the periodontium. These chronic tissue-destructive inflammatory...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Ganther, Sean, Radaic, Allan, Malone, Erin, Kamarajan, Pachiyappan, Chang, Nai-Yuan Nicholas, Tafolla, Christian, Zhan, Ling, Fenno, J. Christopher, Kapila, Yvonne L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301614/
https://ncbi.nlm.nih.gov/pubmed/34255809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009311
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