Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue

Ischemic stroke is caused by a thromboembolic occlusion of a major cerebral artery, with the impaired blood flow triggering neuroinflammation and subsequent neuronal damage. Both the innate immune system (e.g., neutrophils, monocytes/macrophages) in the acute ischemic stroke phase and the adaptive i...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Ponsaerts, Laura, Alders, Lotte, Schepers, Melissa, de Oliveira, Rúbia Maria Weffort, Prickaerts, Jos, Vanmierlo, Tim, Bronckaers, Annelies
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301462/
https://ncbi.nlm.nih.gov/pubmed/34206420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9070703
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