Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1) receptors. Mainly under acidic conditions, it...

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Publicado no:Biomedicines
Main Authors: Horváth, Ádám István, Szentes, Nikolett, Tékus, Valéria, Payrits, Maja, Szőke, Éva, Oláh, Emőke, Garami, András, Fliszár-Nyúl, Eszter, Poór, Miklós, Sár, Cecília, Kálai, Tamás, Pál, Szilárd, Percze, Krisztina, Scholz, Éva Nagyné, Mészáros, Tamás, Tóth, Blanka, Mátyus, Péter, Helyes, Zsuzsanna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301340/
https://ncbi.nlm.nih.gov/pubmed/34209525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9070749
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