Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation

SIMPLE SUMMARY: Down Syndrome, which is due to the presence of three copies of chromosome 21, always presents with mental retardation, possibly caused by defects in the development of neurons. In recent years, it has been shown that cells and tissues in Down syndrome manifest alterations in the func...

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Vydáno v:Biology (Basel)
Hlavní autoři: Mollo, Nunzia, Esposito, Matteo, Aurilia, Miriam, Scognamiglio, Roberta, Accarino, Rossella, Bonfiglio, Ferdinando, Cicatiello, Rita, Charalambous, Maria, Procaccini, Claudio, Micillo, Teresa, Genesio, Rita, Calì, Gaetano, Secondo, Agnese, Paladino, Simona, Matarese, Giuseppe, Vita, Gabriella De, Conti, Anna, Nitsch, Lucio, Izzo, Antonella
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301075/
https://ncbi.nlm.nih.gov/pubmed/34209429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology10070609
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