An Unexpected Oxidosqualene Cyclase Active Site Architecture in the Iris tectorum Multifunctional α-Amyrin Synthase

Ordered polycyclization catalyzed by oxidosqualene synthases (OSCs) morph a common linear precursor into structurally complex and diverse triterpene scaffolds with varied bioactivities. We identified three OSCs from Iris tectorum. ItOSC2 is a rare multifunctional α-amyrin synthase. Sequence comparis...

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Pubblicato in:ACS Catal
Autori principali: Wu, Shidan, Zhang, Fan, Xiong, Wenbo, Molnár, István, Liang, Jincai, Ji, Aijia, Wang, Caixia, Wang, Shengliang, Liu, Zhongqiu, Wu, Ruibo, Duan, Lixin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8297885/
https://ncbi.nlm.nih.gov/pubmed/34306805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.0c03231
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