SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway

The efficacy of corticosteroids and its use for the treatment of SARS-CoV-2 infections is controversial. In this study, using data sets of SARS-CoV-2 infected lung tissues and nasopharyngeal swabs, as well as in vitro experiments, we show that SARS-CoV-2 infection significantly downregulates DUSP1 e...

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Udgivet i:Eur J Pharmacol
Main Authors: Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Goel, Swati, Hafezi, Shirin, Assiri, Rasha, Al-Muhsen, Saleh, Hamid, Qutayba, Halwani, Rabih
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier B.V. 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295491/
https://ncbi.nlm.nih.gov/pubmed/34303662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2021.174374
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