FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation

FUsed in Sarcoma (FUS) is a multifunctional RNA binding protein (RBP). FUS mutations lead to its cytoplasmic mislocalization and cause the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Here, we use mouse and human models with endogenous ALS-associated mutations to study the early co...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Adv
मुख्य लेखकों: Birsa, Nicol, Ule, Agnieszka M., Garone, Maria Giovanna, Tsang, Brian, Mattedi, Francesca, Chong, P. Andrew, Humphrey, Jack, Jarvis, Seth, Pisiren, Melis, Wilkins, Oscar G., Nosella, Micheal L., Devoy, Anny, Bodo, Cristian, de la Fuente, Rafaela Fernandez, Fisher, Elizabeth M. C., Rosa, Alessandro, Viero, Gabriella, Forman-Kay, Julie D., Schiavo, Giampietro, Fratta, Pietro
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Association for the Advancement of Science 2021
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294762/
https://ncbi.nlm.nih.gov/pubmed/34290090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf8660
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