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Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs

During feeding, a tick's mouthpart penetrates the host's skin and damages tissues and small blood vessels, triggering the extrinsic coagulation and lectin complement pathways. To elude these defense mechanisms, ticks secrete multiple anticoagulant proteins and complement system inhibitors...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Denisov, Stepan S., Ippel, Johannes H., Castoldi, Elisabetta, Mans, Ben J., Hackeng, Tilman M., Dijkgraaf, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294578/
https://ncbi.nlm.nih.gov/pubmed/34118237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100865
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