Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication

Alcohol is among the most widely used psychoactive substances worldwide. Ethanol metabolites such as acetate, thought to be primarily the result of ethanol breakdown by hepatic aldehyde dehydrogenase 2 (ALDH2), contribute to alcohol’s behavioural effects and alcoholism. Here, we show that ALDH2 is e...

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Udgivet i:Nat Metab
Main Authors: Jin, Shiyun, Cao, Qi, Yang, Fanghan, Zhu, Hongying, Xu, Su, Chen, Qi, Wang, Ziyi, Lin, Yuhong, Cinar, Resat, Pawlosky, Robert J., Zhang, Ye, Xiong, Wei, Gao, Bin, Koob, George F., Lovinger, David M., Zhang, Li
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294184/
https://ncbi.nlm.nih.gov/pubmed/33758417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-021-00357-z
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