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Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy
Gliomas are the most common and lethal malignant tumor in the central nervous system. The tumor oncogene sphingosine kinase 2 (SphK2) was previously found to be upregulated in glioma tissues and enhance glioma cell epithelial-to-mesenchymal transition through the AKT/β-catenin pathway. Nevertheless,...
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| Pubblicato in: | Front Cell Neurosci |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8292629/ https://ncbi.nlm.nih.gov/pubmed/34305532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.660354 |
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