Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment

Giant cell tumor of bone (GCTB) is an intermediate malignant bone tumor that is locally aggressive and rarely metastasizes. Denosumab, which is a receptor activator of nuclear factor kappa B ligand (RANKL) inhibitor, can be used to treat GCTB. We focused on potential immunotherapy for GCTB and inves...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Toda, Yu, Kohashi, Kenichi, Yamamoto, Hidetaka, Ishihara, Shin, Ito, Yoshihiro, Susuki, Yosuke, Kawaguchi, Kengo, Kiyozawa, Daisuke, Takamatsu, Dai, Kinoshita, Izumi, Yamada, Yuichi, Maehara, Junki, Kimura, Atsushi, Tamiya, Sadafumi, Taguchi, Kenichi, Matsunobu, Tomoya, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Mawatari, Masaaki, Oda, Yoshinao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292371/
https://ncbi.nlm.nih.gov/pubmed/34285260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94022-w
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