MicroRNA-338 inhibition protects against focal cerebral ischemia and preserves mitochondrial function in vitro in astrocytes and neurons via COX4I1.

Brain-enriched microRNA-338 (miR-338) is known to play a central role in brain mitochondrial function, however the role of miR-338 in stroke injury remains unknown. This study investigated the role of miR-338 in injury from transient focal cerebral ischemia in mice, and in cell survival and mitochon...

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Gepubliceerd in:Mitochondrion
Hoofdauteurs: Li, Le, Voloboueva, Ludmila, Griffiths, Brian B., Xu, Lijun, Giffard, Rona G., Stary, Creed M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292173/
https://ncbi.nlm.nih.gov/pubmed/33933660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2021.04.013
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