PTHrP drives pancreatic cancer growth and metastasis and reveals a new therapeutic vulnerability

Pancreatic cancer metastasis is a leading cause of cancer-related deaths, yet very little is understood regarding the underlying biology. As a result, targeted therapies to inhibit metastasis are lacking. Here, we report that the parathyroid hormone-related protein (PTHrP encoded by PTHLH) is freque...

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Bibliografiset tiedot
Julkaisussa:Cancer Discov
Päätekijät: Pitarresi, Jason R., Norgard, Robert J., Chiarella, Anna M., Suzuki, Kensuke, Bakir, Basil, Sahu, Varun, Li, Jinyang, Zhao, Jun, Marchand, Benoît, Wengyn, Maximilian D., Hsieh, Antony, Kim, Il-Kyu, Zhang, Amy, Sellin, Karine, Lee, Vivian, Takano, Shigetsugu, Miyahara, Yoji, Ohtsuka, Masayuki, Maitra, Anirban, Notta, Faiyaz, Kremer, Richard, Stanger, Ben Z., Rustgi, Anil K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292165/
https://ncbi.nlm.nih.gov/pubmed/33589425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1098
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