An Inhibitor Screen identifies Histone-modifying Enzymes as Mediators of Polymer-mediated Transgene Expression from Plasmid DNA

Effective transgene expression in mammalian cells relies on successful delivery, cytoplasmic trafficking, and nuclear translocation of the delivered vector, but delivery is impeded by several formidable physicochemical barriers on the surface of and within the target cell. Although methods to overco...

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Bibliografische gegevens
Gepubliceerd in:J Control Release
Hoofdauteurs: Christensen, Matthew D., Nitiyanandan, Rajeshwar, Meraji, Seyedehmelika, Davis, René, Godeshala, Sudhakar, Goklany, Sheba, Haynes, Karmella, Rege, Kaushal
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291970/
https://ncbi.nlm.nih.gov/pubmed/29964136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.06.030
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