Silencing cyclophilin A improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via MAPK/NF-kb signaling pathway

Cyclophilin A is increased in the plasm of diabetic patients, while its effects on high glucose (HG)-stimulated pancreatic β-cells are still pending. The aim of this research is to investigate the effects of cyclophilin A inhibition on HG-challenged pancreatic β-cells. For investigating the effects...

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Dettagli Bibliografici
Pubblicato in:Bioengineered
Autori principali: Li, Tangying, Quan, Huibiao, Zhang, Huachuan, Lin, Leweihua, Ou, Qianying, Chen, Kaining
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291783/
https://ncbi.nlm.nih.gov/pubmed/32970961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21655979.2020.1823729
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