Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi

Background: Many physiological effects of thyroid hormone (TH) are mediated by its canonical action via nuclear receptors (TH receptor α and β [TRα and TRβ]) to regulate transcription of target genes. Heterozygous dominant negative mutations in human TRα mediate resistance to thyroid hormone alpha (...

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Bibliografiska uppgifter
I publikationen:Thyroid
Huvudupphovsmän: Di Cicco, Emery, Moran, Carla, Visser, W. Edward, Nappi, Annarita, Schoenmakers, Erik, Todd, Pamela, Lyons, Greta, Dattani, Mehul, Ambrosio, Raffaele, Parisi, Silvia, Salvatore, Domenico, Chatterjee, Krishna, Dentice, Monica
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mary Ann Liebert, Inc., publishers 2021
Ämnen:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290313/
https://ncbi.nlm.nih.gov/pubmed/33509032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2020.0391
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