A deep learning model for predicting next-generation sequencing depth from DNA sequence

Targeted high-throughput DNA sequencing is a primary approach for genomics and molecular diagnostics, and more recently as a readout for DNA information storage. Oligonucleotide probes used to enrich gene loci of interest have different hybridization kinetics, resulting in non-uniform coverage that...

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Udgivet i:Nat Commun
Main Authors: Zhang, Jinny X., Yordanov, Boyan, Gaunt, Alexander, Wang, Michael X., Dai, Peng, Chen, Yuan-Jyue, Zhang, Kerou, Fang, John Z., Dalchau, Neil, Li, Jiaming, Phillips, Andrew, Zhang, David Yu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290051/
https://ncbi.nlm.nih.gov/pubmed/34282137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24497-8
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