M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway

Hepatocellular carcinoma (HCC) is a common malignancy. CD8(+) T cell-mediated immune response is critical for the inhibition of HCC progression. M2 macrophages participate in HCC progression. This study set out to investigate the effect of M2 macrophage-derived extracellular vesicles (EVs) on CD8(+)...

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Bibliografiske detaljer
Udgivet i:Cell Death Discov
Main Authors: Pu, Jian, Xu, Zuoming, Nian, Jiahui, Fang, Quan, Yang, Meng, Huang, Youguan, Li, Wenchuan, Ge, Bin, Wang, Jianchu, Wei, Huamei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Editorial
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289864/
https://ncbi.nlm.nih.gov/pubmed/34282135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00556-3
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