CD16(+)CD163(+) monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants

Necrotizing enterocolitis (NEC) is a severe gastrointestinal complication of prematurity. Using suspension and imaging mass cytometry coupled with single-cell RNA sequencing, we demonstrate severe inflammation in patients with NEC. NEC mucosa could be subtyped by an influx of three distinct neutroph...

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Pubblicato in:J Exp Med
Autori principali: Olaloye, Oluwabunmi O., Liu, Peng, Toothaker, Jessica M., McCourt, Blake T., McCourt, Collin C., Xiao, Jenny, Prochaska, Erica, Shaffer, Spenser, Werner, Lael, Gringauz, Jordan, Good, Misty, Goldsmith, Jeffrey D., An, Xiaojing, Wang, Fujing, Snapper, Scott B., Shouval, Dror, Chen, Kong, Tseng, George, Konnikova, Liza
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289692/
https://ncbi.nlm.nih.gov/pubmed/34269788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200344
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