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Tumor Response End Points as Surrogates for Overall Survival in Immune Checkpoint Inhibitor Trials: A Systematic Review and Meta-Analysis

PURPOSE: Many immune checkpoint inhibitors (ICIs) have been approved on the basis of tumor response end points in nonrandomized trials, including objective response rate (ORR) and duration and depth of response. We aimed to assess the validity of these end points as surrogate end points for overall...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Kok, Peey-Sei, Yoon, Won-Hee, Lord, Sally, Marschner, Ian, Friedlander, Michael, Lee, Chee Khoon
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289006/
https://ncbi.nlm.nih.gov/pubmed/34296055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.21.00108
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