CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro. In this perspective, we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macu...

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發表在:Natl Sci Rev
Main Authors: Zhou, Changyang, Hu, Xinde, Tang, Cheng, Liu, Wenjia, Wang, Shaoran, Zhou, Yingsi, Zhao, Qimeng, Bo, Qiyu, Shi, Linyu, Sun, Xiaodong, Zhou, Haibo, Yang, Hui
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
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Perspectives
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288881/
https://ncbi.nlm.nih.gov/pubmed/34692105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nsr/nwaa033
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