Wild-type HIV infection after treatment with lentiviral gene therapy for β-thalassemia

Betibeglogene autotemcel (beti-cel) gene therapy (GT) for patients with transfusion-dependent β-thalassemia uses autologous CD34(+) cells transduced with BB305 lentiviral vector (LVV), which encodes a modified β-globin gene. BB305 LVV also contains select HIV sequences for viral packaging, reverse t...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Hongeng, Suradej, Anurathapan, Usanarat, Songdej, Duantida, Phuphuakrat, Angsana, Jongrak, Kesinee, Parsons, Geoffrey, Deary, Briana, Bonner, Melissa, Veres, Gabor, Asmal, Mohammed
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2021
Sujets:
Exceptional Case Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288666/
https://ncbi.nlm.nih.gov/pubmed/34196676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003680
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