Individualized genetic makeup that controls natural killer cell function influences the efficacy of isatuximab immunotherapy in patients with multiple myeloma

BACKGROUND: Phase IIb clinical trial with isatuximab (Isa)-lenalidomide (Len)-dexamethasone (Dex) showed an improved progression-free survival (PFS) in patients with relapsed or refractory multiple myeloma (RRMM), but the efficacy varied by patient. Antibody-dependent cell-mediated cytotoxicity (ADC...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Sun, Haibo, Martin, Thomas G, Marra, John, Kong, Denice, Keats, Jonathon, Macé, Sandrine, Chiron, Marielle, Wolf, Jeffrey L, Venstrom, Jeffrey M, Rajalingam, Raja
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Clinical/Translational Cancer Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287616/
https://ncbi.nlm.nih.gov/pubmed/34272304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002958
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