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The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes

Transcription factors (TFs) regulate transcription of their target genes by identifying and binding to regulatory regions of the genome among billions of potential non-specific decoy sites, a task that is often presented as a ‘needle in the haystack’ challenge. The TF search process is now well unde...

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Bibliografische gegevens
Gepubliceerd in:Biochem Soc Trans
Hoofdauteurs: Mazzocca, Matteo, Fillot, Tom, Loffreda, Alessia, Gnani, Daniela, Mazza, Davide
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Portland Press Ltd. 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286828/
https://ncbi.nlm.nih.gov/pubmed/34003257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200709
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