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Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk

Although prostate cancer is known to have a strong genetic basis and is influenced by both common and rare variants, the ability to investigate the combined effect of such genetic risk factors has been limited to date. We conducted an investigation of 81 094 men from the UK Biobank, including 3568 p...

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Detalhes bibliográficos
Publicado no:Eur Urol
Main Authors: Darst, Burcu F., Sheng, Xin, Eeles, Rosalind A., Kote-Jarai, Zsofia, Conti, David V., Haiman, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286329/
https://ncbi.nlm.nih.gov/pubmed/33941403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2021.04.013
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