Caloric restriction impairs regulatory T-cells within the tumor microenvironment after radiation and primes effector T-cells

Outcomes for triple negative breast cancer (TNBC) are poor and may be improved by increasing CD8+ tumor infiltrating lymphocytes (TIL) to augment anti-tumor immunity. Radiation (RT) can promote immunogenic cell death with increased anti-tumor T-cell activity but also stimulates suppressive regulator...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Manukian, Gregor, Kivolowitz, Charles, DeAngelis, Tiziana, Shastri, Anuradha, Savage, Jason E., Camphausen, Kevin, Rodeck, Ulrich, Zarif, Jelani, Simone, Nicole L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286289/
https://ncbi.nlm.nih.gov/pubmed/33647370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2021.02.029
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