Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor

Dynamin oligomerizes into helical filaments on tubular membrane templates and, through constriction, cleaves them in a GTPase-driven way. Structural observations of GTP-dependent cross-bridges between neighboring filament turns have led to the suggestion that dynamin operates as a molecular ratchet...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ganichkin, Oleg M., Vancraenenbroeck, Renee, Rosenblum, Gabriel, Hofmann, Hagen, Mikhailov, Alexander S., Daumke, Oliver, Noel, Jeffrey K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285958/
https://ncbi.nlm.nih.gov/pubmed/34244431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101144118
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