Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis

BACKGROUND: Meropenem dosing for septic critically patients is difficult due to pathophysiological changes associated with sepsis as well as supportive symptomatic therapies. A prospective single-center study assessed whether fluid retention alters meropenem pharmacokinetics and the achievement of t...

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Bibliografiske detaljer
Udgivet i:Crit Care
Main Authors: Pařízková, Renata Černá, Martínková, Jiřina, Havel, Eduard, Šafránek, Petr, Kaška, Milan, Astapenko, David, Bezouška, Jan, Chládek, Jaroslav, Černý, Vladimír
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285835/
https://ncbi.nlm.nih.gov/pubmed/34274013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-021-03680-9
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