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Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection
SARS-CoV and SARS-CoV-2 encode spike proteins that bind human ACE2 on the cell surface to enter target cells during infection. A small fraction of humans encode variants of ACE2, thus altering the biochemical properties at the protein interaction interface. These and other ACE2 coding mutants can re...
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| Publicado en: | PLoS Pathog |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8284657/ https://ncbi.nlm.nih.gov/pubmed/34270613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009715 |
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