PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages

It was previously shown that secretion of PE-PGRS and PPE-MPTR proteins is abolished in clinical M. tuberculosis isolates with a deletion in the ppe38-71 operon, which is associated with increased virulence. Here we investigate the proteins dependent on PPE38 for their secretion and their role in th...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Gallant, James, Heunis, Tiaan, Beltran, Caroline, Schildermans, Karin, Bruijns, Sven, Mertens, Inge, Bitter, Wilbert, Sampson, Samantha L.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284050/
https://ncbi.nlm.nih.gov/pubmed/34276695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.702359
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